Cerebral Hemodynamics in CADASIL Before and After Acetazolamide Challenge Assessed With MRI Bolus Tracking | Zendy

Hugues Chabriat | Zendy; Sabina Pappatà | Zendy; Leif Østergaard | Zendy; Chris Clark | Zendy; Mathilde PachotClouard | Zendy; Katayoun Vahedi | Zendy; Antoinette Jobert | Zendy; Denis Le Bihan | Zendy; MarieGermaine Bousser | Zendy

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Cerebral Hemodynamics in CADASIL Before and After Acetazolamide Challenge Assessed With MRI Bolus Tracking

Author(s) -

Hugues Chabriat,

Sabina Pappatà,

Leif Østergaard,

Chris Clark,

Mathilde PachotClouard,

Katayoun Vahedi,

Antoinette Jobert,

Denis Le Bihan,

MarieGermaine Bousser

Publication year - 2000

Publication title -

stroke

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.397

H-Index - 319

eISSN - 1524-4628

pISSN - 0039-2499

DOI - 10.1161/01.str.31.8.1904

Subject(s) - cadasil , medicine , white matter , hyperintensity , cerebral blood flow , acetazolamide , leukoencephalopathy , hemodynamics , cardiology , magnetic resonance imaging , pathology , radiology

White matter lesions in cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) are underlaid by severe ultrastructural changes of the arteriolar wall. Although chronic ischemia is presumed to cause the tissue lesions, the pattern of perfusion abnormalities and hemodynamic reserve in CADASIL, particularly within the white matter, remains unknown.

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