Serial Measurement of Vascular Endothelial Growth Factor and Transforming Growth Factor-β1 in Serum of Patients With Acute Ischemic Stroke | Zendy

Mark Slevin | Zendy; Jerzy Krupiński | Zendy; Agnieszka Słowik | Zendy; P. R. Kumar | Zendy; Andrzej Szczudlik | Zendy; John Gaffney | Zendy

Open Access

Serial Measurement of Vascular Endothelial Growth Factor and Transforming Growth Factor-β1 in Serum of Patients With Acute Ischemic Stroke

Author(s) -

Mark Slevin,

Jerzy Krupiński,

Agnieszka Słowik,

P. R. Kumar,

Andrzej Szczudlik,

John Gaffney

Publication year - 2000

Publication title -

stroke

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.397

H-Index - 319

eISSN - 1524-4628

pISSN - 0039-2499

DOI - 10.1161/01.str.31.8.1863

Subject(s) - medicine , vascular endothelial growth factor , stroke (engine) , leukocytosis , penumbra , angiogenesis , transforming growth factor , vascular disease , cardiology , gdf15 , gastroenterology , ischemia , vegf receptors , mechanical engineering , engineering

Both vascular endothelial growth factor (VEGF) and transforming growth factor-beta1 (TGF-beta1) are expressed in higher than normal concentrations in the penumbra of patients after ischemic stroke. Because both cytokines are central to the processes of angiogenesis, tissue inflammation, and fibrosis, we performed serial measurements of these cytokines in patients with cerebral infarction and determined their relationship to stroke etiology and volume.

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