Oxygen-Glucose Deprivation Induces Inducible Nitric Oxide Synthase and Nitrotyrosine Expression in Cerebral Endothelial Cells | Zendy

Jan Xu | Zendy; Luming He | Zendy; S. Hinan Ahmed | Zendy; Sha-Wei Chen | Zendy; Mark P. Goldberg | Zendy; Joseph S. Beckman | Zendy; Chung Y. Hsu | Zendy

Open Access

Oxygen-Glucose Deprivation Induces Inducible Nitric Oxide Synthase and Nitrotyrosine Expression in Cerebral Endothelial Cells

Author(s) -

Jan Xu,

Luming He,

S. Hinan Ahmed,

Sha-Wei Chen,

Mark P. Goldberg,

Joseph S. Beckman,

Chung Y. Hsu

Publication year - 2000

Publication title -

stroke

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.397

H-Index - 319

eISSN - 1524-4628

pISSN - 0039-2499

DOI - 10.1161/01.str.31.7.1744

Subject(s) - nitrotyrosine , nitric oxide synthase , microbiology and biotechnology , programmed cell death , apoptosis , tunel assay , terminal deoxynucleotidyl transferase , peroxynitrite , western blot , dna fragmentation , nitric oxide , biology , medicine , biochemistry , endocrinology , superoxide , enzyme , gene

The cerebral endothelial cells (ECs) are a primary target of hypoxic or ischemic brain insults. EC damage may contribute to postischemic secondary injury. Massive production of NO after inducible NO synthase (iNOS) expression has been implicated in cell death. This study aimed to characterize bovine cerebral EC death in relation to iNOS expression after oxygen-glucose deprivation (OGD) in vitro.

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