Open AccessHypertonic Saline Worsens Infarct Volume After Transient Focal Ischemia in Rats
Author(s) -
Anish Bhardwaj,
Izumi Harukuni,
Stephanie J. Murphy,
Nabil J. Alkayed,
Barbara J. Crain,
Raymond C. Koehler,
Patricia D. Hurn,
Richard J. Traystman
Publication year - 2000
Publication title -
stroke
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.397
H-Index - 319
eISSN - 1524-4628
pISSN - 0039-2499
DOI - 10.1161/01.str.31.7.1694
Subject(s) - medicine , anesthesia , saline , ischemia , hypertonic saline , bolus (digestion) , cerebral blood flow , reperfusion injury , evans blue , edema
Hypertonic saline (HS) has been advocated as a hyperosmolar agent for the treatment of cerebral edema, especially after traumatic brain injury. We tested the hypothesis that continuous intravenous HS administered during reperfusion from transient focal cerebral ischemia attenuates infarct volume.
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