Brain Tissue Sodium Is a Ticking Clock Telling Time After Arterial Occlusion in Rat Focal Cerebral Ischemia | Zendy

Yang Wang | Zendy; Weixing Hu | Zendy; Alejandro D. Perez-Trepichio | Zendy; Thian C. Ng | Zendy; Anthony J. Furlan | Zendy; Anthony W. Majors | Zendy; Stephen C. Jones | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

Brain Tissue Sodium Is a Ticking Clock Telling Time After Arterial Occlusion in Rat Focal Cerebral Ischemia

Author(s) -

Yang Wang,

Weixing Hu,

Alejandro D. Perez-Trepichio,

Thian C. Ng,

Anthony J. Furlan,

Anthony W. Majors,

Stephen C. Jones

Publication year - 2000

Publication title -

stroke

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.397

H-Index - 319

eISSN - 1524-4628

pISSN - 0039-2499

DOI - 10.1161/01.str.31.6.1386

Subject(s) - medicine , cerebral blood flow , ischemia , occlusion , middle cerebral artery , thrombolysis , effective diffusion coefficient , anesthesia , stroke (engine) , cardiology , magnetic resonance imaging , radiology , mechanical engineering , myocardial infarction , engineering

Many patients with acute stroke are excluded from receiving thrombolysis agents within the necessary time limit (3 or 6 hours from stroke onset) because they or their family members are unable provide the time of stroke onset. Brain tissue sodium concentration ([Na(+)]) increases gradually and incessantly during the initial hours of experimental focal cerebral ischemia but only in severely damaged brain regions. We propose that this steady increase in [Na(+)] can be used to estimate the time after arterial occlusion in the rat middle cerebral artery occlusion model of ischemic stroke.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research