Hypertonic Mannitol Loading of NF-κB Transcription Factor Decoys in Human Brain Microvascular Endothelial Cells Blocks Upregulation of ICAM-1 | Zendy

David C. Hess | Zendy; Eugene F. Howard | Zendy; Charles Cheng | Zendy; James E. Carroll | Zendy; W. David Hill | Zendy

Open Access

Hypertonic Mannitol Loading of NF-κB Transcription Factor Decoys in Human Brain Microvascular Endothelial Cells Blocks Upregulation of ICAM-1

Author(s) -

David C. Hess,

Eugene F. Howard,

Charles Cheng,

James E. Carroll,

W. David Hill

Publication year - 2000

Publication title -

stroke

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.397

H-Index - 319

eISSN - 1524-4628

pISSN - 0039-2499

DOI - 10.1161/01.str.31.5.1179

Subject(s) - downregulation and upregulation , endothelial stem cell , tumor necrosis factor alpha , medicine , transcription factor , decoy , nf κb , nfkb1 , icam 1 , microbiology and biotechnology , cell adhesion molecule , biology , immunology , inflammation , receptor , in vitro , biochemistry , gene

An acute inflammatory response exacerbates tissue injury during acute ischemic stroke. The transcription factor nuclear factor (NF)-kappaB plays a key role in endothelial cell activation and the inflammatory response. Targeted genetic disruption of NF-kappaB activation in cerebral endothelial cells may be protective in stroke. We determined whether a NF-kappaB transcription factor decoy (TFD) could block intercellular adhesion molecule (ICAM)-1 upregulation, an indicator of endothelial cell activation.

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