σ 1 -Receptor Ligand 4-Phenyl-1-(4-Phenylbutyl)-Piperidine Affords Neuroprotection From Focal Ischemia With Prolonged Reperfusion | Zendy

Izumi Harukuni | Zendy; Anish Bhardwaj | Zendy; Amanda B. Shaivitz | Zendy; A. Courtney DeVries | Zendy; Edythe D. London | Zendy; Patricia D. Hurn | Zendy; Richard J. Traystman | Zendy; Jeffrey R. Kirsch | Zendy

Open Access

σ ₁ -Receptor Ligand 4-Phenyl-1-(4-Phenylbutyl)-Piperidine Affords Neuroprotection From Focal Ischemia With Prolonged Reperfusion

Author(s) -

Izumi Harukuni,

Anish Bhardwaj,

Amanda B. Shaivitz,

A. Courtney DeVries,

Edythe D. London,

Patricia D. Hurn,

Richard J. Traystman,

Jeffrey R. Kirsch

Publication year - 2000

Publication title -

stroke

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.397

H-Index - 319

eISSN - 1524-4628

pISSN - 0039-2499

DOI - 10.1161/01.str.31.4.976

Subject(s) - medicine , neuroprotection , anesthesia , ischemia , infarction , saline , myocardial infarction

We previously showed that the intravenous administration of the potent final sigma(1)-receptor ligand 4-phenyl-1-(4-phenylbutyl)-piperidine (PPBP) provides neuroprotection against transient focal cerebral ischemia and that the protection depends on treatment duration. We tested the hypothesis that PPBP would provide neuroprotection in a model of transient focal ischemia and 7 days of reperfusion in the rat as assessed with neurobehavioral outcome and infarction volume.

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