Impaired Endothelial Function in Transgenic Mice Expressing Both Human Renin and Human Angiotensinogen | Zendy

Sean P. Didion | Zendy; Curt D. Sigmund | Zendy; Frank M. Faraci | Zendy

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Impaired Endothelial Function in Transgenic Mice Expressing Both Human Renin and Human Angiotensinogen

Author(s) -

Sean P. Didion,

Curt D. Sigmund,

Frank M. Faraci

Publication year - 2000

Publication title -

stroke

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.397

H-Index - 319

eISSN - 1524-4628

pISSN - 0039-2499

DOI - 10.1161/01.str.31.3.760

Subject(s) - medicine , endocrinology , acetylcholine , genetically modified mouse , endothelial dysfunction , vasodilation , sodium nitroprusside , renin–angiotensin system , nitric oxide , transgene , blood pressure , biology , biochemistry , gene

Chronic hypertension is a risk factor for carotid vascular disease and stroke. Mechanisms that account for alterations in carotid and cerebral vascular function during hypertension are poorly defined and based almost exclusively on studies in the spontaneously hypertensive rat, a model in which hypertension has an unknown etiology and in which the genetic background is dissimilar to the most commonly used normotensive control, the Wistar-Kyoto rat.

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