Stroke in Estrogen Receptor-α–Deficient Mice | Zendy

Kenji Sampei | Zendy; Shozo Goto | Zendy; Nabil J. Alkayed | Zendy; Barbara J. Crain | Zendy; Kenneth S. Korach | Zendy; Richard J. Traystman | Zendy; Gregory E. Demas | Zendy; Randy J. Nelson | Zendy; Patricia D. Hurn | Zendy

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Stroke in Estrogen Receptor-α–Deficient Mice

Author(s) -

Kenji Sampei,

Shozo Goto,

Nabil J. Alkayed,

Barbara J. Crain,

Kenneth S. Korach,

Richard J. Traystman,

Gregory E. Demas,

Randy J. Nelson,

Patricia D. Hurn

Publication year - 2000

Publication title -

stroke

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.397

H-Index - 319

eISSN - 1524-4628

pISSN - 0039-2499

DOI - 10.1161/01.str.31.3.738

Subject(s) - medicine , stroke (engine) , estrogen receptor , estrogen , cerebral blood flow , infarction , endocrinology , ischemia , middle cerebral artery , cerebral infarction , pathology , myocardial infarction , cancer , breast cancer , mechanical engineering , engineering

Recent evidence suggests that endogenous estrogens or hormone replacement therapy can ameliorate brain damage from experimental stroke. Protective mechanisms involve enhanced cerebral vasodilation during ischemic stress as well as direct preservation of neuronal viability. We hypothesized that if the intracellular estrogen receptor subtype-alpha (ERalpha) is important to estrogen's signaling in the ischemic brain, then ERalpha-deficient (knockout) (ERalphaKO) female mice would sustain exaggerated cerebral infarction damage after middle cerebral artery occlusion.

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