Relating MRI Changes to Motor Deficit After Ischemic Stroke by Segmentation of Functional Motor Pathways | Zendy

Roberto Piñeiro | Zendy; Sarah T. Pendlebury | Zendy; Stephen M. Smith | Zendy; David E. Flitney | Zendy; Andrew M. Blamire | Zendy; Peter Styles | Zendy; Paul M. Matthews | Zendy

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Relating MRI Changes to Motor Deficit After Ischemic Stroke by Segmentation of Functional Motor Pathways

Author(s) -

Roberto Piñeiro,

Sarah T. Pendlebury,

Stephen M. Smith,

David E. Flitney,

Andrew M. Blamire,

Peter Styles,

Paul M. Matthews

Publication year - 2000

Publication title -

stroke

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.397

H-Index - 319

eISSN - 1524-4628

pISSN - 0039-2499

DOI - 10.1161/01.str.31.3.672

Subject(s) - medicine , internal capsule , stroke (engine) , neurological deficit , lesion , magnetic resonance imaging , motor cortex , physical medicine and rehabilitation , hemiparesis , motor impairment , neuroscience , cardiology , radiology , pathology , anesthesia , psychology , white matter , mechanical engineering , stimulation , engineering

Infarct size on T2-weighted MRI correlates only modestly with outcome, particularly for small strokes. This may be largely because of differences in the locations of infarcts and consequently in the functional pathways that are damaged. To test this hypothesis quantitatively, we developed a "mask" of the corticospinal pathway to determine whether the extent of stroke intersection with the pathway would be more closely related to clinical motor deficit and axonal injury in the descending motor pathways than total stroke lesion volume.

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