Mechanism of Endothelin-1–Induced Contraction in Rabbit Basilar Artery | Zendy

Alexander Y. Zubkov | Zendy; K. Shadon Rollins | Zendy; Andrew D. Parent | Zendy; John H. Zhang | Zendy

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Mechanism of Endothelin-1–Induced Contraction in Rabbit Basilar Artery

Author(s) -

Alexander Y. Zubkov,

K. Shadon Rollins,

Andrew D. Parent,

John H. Zhang

Publication year - 2000

Publication title -

stroke

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.397

H-Index - 319

eISSN - 1524-4628

pISSN - 0039-2499

DOI - 10.1161/01.str.31.2.526

Subject(s) - calphostin c , wortmannin , staurosporine , medicine , protein kinase c , calphostin , contraction (grammar) , basilar artery , tyrosine kinase , mapk/erk pathway , endocrinology , pharmacology , kinase , microbiology and biotechnology , biology , phosphatidylinositol , receptor

Endothelin-1 (ET-1) is suggested to be a major cause of cerebral vasospasm after subarachnoid hemorrhage. However, the mechanism of ET-1-induced contraction in cerebral arteries remains unclear. This study was undertaken to demonstrate the possible role of protein tyrosine kinase (PTK), mitogen-activated protein kinase (MAPK), and protein kinase C (PKC) in ET-1-induced contraction.

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