Augmented Vasoconstriction and Thromboxane Formation by 15-F 2t -Isoprostane (8-Iso-Prostaglandin F 2α ) in Immature Pig Periventricular Brain Microvessels | Zendy

Xin Hou | Zendy; Fernand Gobeil | Zendy; Krishna G. Peri | Zendy; Giovanna Speranza | Zendy; Anne Marilise Marrache | Zendy; Pierre Lachapelle | Zendy; Jackson Roberts | Zendy; Daya R. Varma | Zendy; Sylvain Chemtob | Zendy

Open Access

Augmented Vasoconstriction and Thromboxane Formation by 15-F _2t -Isoprostane (8-Iso-Prostaglandin F _2α ) in Immature Pig Periventricular Brain Microvessels

Author(s) -

Xin Hou,

Fernand Gobeil,

Krishna G. Peri,

Giovanna Speranza,

Anne Marilise Marrache,

Pierre Lachapelle,

Jackson Roberts,

Daya R. Varma,

Sylvain Chemtob

Publication year - 2000

Publication title -

stroke

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.397

H-Index - 319

eISSN - 1524-4628

pISSN - 0039-2499

DOI - 10.1161/01.str.31.2.516

Subject(s) - medicine , isoprostane , endocrinology , thromboxane , vasoconstriction , fetus , prostaglandin , oxidative stress , lipid peroxidation , platelet , biology , pregnancy , genetics

Oxidant stress, especially in the premature, plays a major role in the pathogenesis of hypoxic-ischemic encephalopathies mostly manifested in the periventricular region. We studied the vasomotor mode of actions of the peroxidation product 15-F(2t)-isoprostane (15-F(2t)-IsoP) (8-iso-prostaglandin F(2alpha)) on periventricular region during development.

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