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Association Between Platelet Glycoprotein Ibα Genotype and Ischemic Cerebrovascular Disease
Author(s) -
Akira Sonoda,
Mitsuru Murata,
Daisuke Ito,
Norio Tanahashi,
Atsumi Ohta,
Yoko Tada,
Eiko Takeshita,
Tadashi Yoshida,
Ikuo Saito,
Masatoshi Yamamoto,
Yasuo Ikeda,
Yasuo Fukuuchi,
Kiyoaki Watanabe
Publication year - 2000
Publication title -
stroke
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.397
H-Index - 319
eISSN - 1524-4628
pISSN - 0039-2499
DOI - 10.1161/01.str.31.2.493
Subject(s) - medicine , odds ratio , genotype , von willebrand factor , platelet membrane glycoprotein , platelet , platelet glycoprotein gpib ix complex , gastroenterology , glycoprotein ib , confidence interval , cardiology , logistic regression , risk factor , genotype frequency , allele frequency , genetics , biology , gene
Platelets play pivotal roles in the development of ischemic cerebrovascular disease (CVD). The platelet glycoprotein (GP) Ib/IX/V complex is a receptor for von Willebrand factor, which plays a major role in the initial phase of platelet activation under high shear stress conditions. This study was designed to investigate the association between a genetic variation of this receptor and the prevalence of CVD.

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