Early [ 11 C]Flumazenil/H 2 O Positron Emission Tomography Predicts Irreversible Ischemic Cortical Damage in Stroke Patients Receiving Acute Thrombolytic Therapy | Zendy

Wolf-Dieter Heiß | Zendy; Lutz Kracht | Zendy; Martin Grond | Zendy; Jobst Rudolf | Zendy; Bernd Bauer | Zendy; K. Wienhard | Zendy; G. Pawlik | Zendy

Open Access

Early [ ¹¹ C]Flumazenil/H ₂ O Positron Emission Tomography Predicts Irreversible Ischemic Cortical Damage in Stroke Patients Receiving Acute Thrombolytic Therapy

Author(s) -

Wolf-Dieter Heiß,

Lutz Kracht,

Martin Grond,

Jobst Rudolf,

Bernd Bauer,

K. Wienhard,

G. Pawlik

Publication year - 2000

Publication title -

stroke

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.397

H-Index - 319

eISSN - 1524-4628

pISSN - 0039-2499

DOI - 10.1161/01.str.31.2.366

Subject(s) - medicine , flumazenil , thrombolysis , stroke (engine) , tissue plasminogen activator , positron emission tomography , brain ischemia , penumbra , cardiology , ischemia , anesthesia , nuclear medicine , benzodiazepine , receptor , myocardial infarction , mechanical engineering , engineering

Central benzodiazepine receptor ligands, such as [(11)C]flumazenil (FMZ), are markers of neuronal integrity and therefore might be useful in the differentiation of functionally and morphologically damaged tissue early in ischemic stroke. We sought to assess the value of a benzodiazepine receptor ligand for the early identification of irreversible ischemic damage to cortical areas that cannot benefit from reperfusion.

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