Stroke Outcome in Double-Mutant Antioxidant Transgenic Mice | Zendy

Kenji Sampei | Zendy; Allen S. Mandir | Zendy; Yoshio Asano | Zendy; Phillip C. Wong | Zendy; Richard J. Traystman | Zendy; Valina L. Dawson | Zendy; Ted M. Dawson | Zendy; Patricia D. Hurn | Zendy

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Stroke Outcome in Double-Mutant Antioxidant Transgenic Mice

Author(s) -

Kenji Sampei,

Allen S. Mandir,

Yoshio Asano,

Phillip C. Wong,

Richard J. Traystman,

Valina L. Dawson,

Ted M. Dawson,

Patricia D. Hurn

Publication year - 2000

Publication title -

stroke

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.397

H-Index - 319

eISSN - 1524-4628

pISSN - 0039-2499

DOI - 10.1161/01.str.31.11.2685

Subject(s) - medicine , superoxide dismutase , middle cerebral artery , stroke (engine) , infarction , superoxide , in vivo , cerebral infarction , ischemia , genetically modified mouse , pathology , reactive oxygen species , endocrinology , transgene , oxidative stress , biology , biochemistry , enzyme , myocardial infarction , mechanical engineering , microbiology and biotechnology , gene , engineering

Both NO and superoxide cytotoxicity are important in experimental stroke; however, it is unclear whether these molecules act within parallel pathological pathways or as coreagents in a common reaction. We examined these alternatives by comparing outcomes after middle cerebral artery occlusion in male and female neuronal NO synthase (nNOS)-deficient (nNOS-/-) or human CuZn superoxide dismutase-overexpressing (hSOD1+/-) mice and a novel strain with both mutations.

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