Heritability of Intracerebral Hemorrhagic Lesions and Cerebral Aneurysms in the Rat | Zendy

Michèle Coutard | Zendy; Huang Wei | Zendy; Mary OsbornePellegrin | Zendy

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Heritability of Intracerebral Hemorrhagic Lesions and Cerebral Aneurysms in the Rat

Author(s) -

Michèle Coutard,

Huang Wei,

Mary OsbornePellegrin

Publication year - 2000

Publication title -

stroke

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.397

H-Index - 319

eISSN - 1524-4628

pISSN - 0039-2499

DOI - 10.1161/01.str.31.11.2678

Subject(s) - medicine , internal elastic lamina , incidence (geometry) , lesion , circle of willis , ligation , pathology , endocrinology , cardiology , artery , physics , optics

Under certain conditions, the Brown Norway (BN) rat is susceptible to intracerebral hemorrhagic vascular (ICV) lesions within the cerebral cortex, whereas the Long-Evans (LE) rat is prone to develop aneurysms in the circle of Willis. The incidence of these 2 pathological phenotypes was studied in progeny of different BNXLE crosses to determine their heritability in these new rat models. In addition, a possible link between ICV lesion occurrence and either the susceptibility to spontaneous rupture of the arterial internal elastic lamina (IEL) or basal plasma angiotensin-converting enzyme (ACE) activity was also studied in back-cross (BC) F1XBN rats, the only second-generation group with a high incidence of ICV lesions.

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