Analysis of Endoglin Expression in Normal Brain Tissue and in Cerebral Arteriovenous Malformations | Zendy

Shunji Matsubara | Zendy; Annie Bourdeau | Zendy; Karel G. terBrugge | Zendy; Christopher Wallace | Zendy; Michelle Letarte | Zendy

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Analysis of Endoglin Expression in Normal Brain Tissue and in Cerebral Arteriovenous Malformations

Author(s) -

Shunji Matsubara,

Annie Bourdeau,

Karel G. terBrugge,

Christopher Wallace,

Michelle Letarte

Publication year - 2000

Publication title -

stroke

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.397

H-Index - 319

eISSN - 1524-4628

pISSN - 0039-2499

DOI - 10.1161/01.str.31.11.2653

Subject(s) - endoglin , adventitia , medicine , pathology , vimentin , endothelium , elastin , cerebral circulation , desmin , mesenchymal stem cell , anatomy , immunohistochemistry , biology , microbiology and biotechnology , stem cell , cd34

A high incidence of arteriovenous malformations (AVMs) is associated with hereditary hemorrhagic telangiectasia type 1. Endoglin, the gene mutated in this disorder, is expressed at reduced levels on blood vessels of these patients. Since endoglin is a component of the transforming growth factor-beta receptor complex critical for vascular development and homeostasis, we determined its expression in sporadic cerebral AVMs and in normal brain vessels.

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