Cyclin D1 and Cdk4 Protein Induction in Motor Neurons After Transient Spinal Cord Ischemia in Rabbits | Zendy

Masahiro Sakurai | Zendy; Takeshi Hayashi | Zendy; Koji Abe | Zendy; Yasuto Itoyama | Zendy; Koichi Tabayashi | Zendy

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Cyclin D1 and Cdk4 Protein Induction in Motor Neurons After Transient Spinal Cord Ischemia in Rabbits

Author(s) -

Masahiro Sakurai,

Takeshi Hayashi,

Koji Abe,

Yasuto Itoyama,

Koichi Tabayashi

Publication year - 2000

Publication title -

stroke

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.397

H-Index - 319

eISSN - 1524-4628

pISSN - 0039-2499

DOI - 10.1161/01.str.31.1.200

Subject(s) - tunel assay , spinal cord , terminal deoxynucleotidyl transferase , medicine , cyclin d1 , motor neuron , neuron , ischemia , pathology , immunohistochemistry , cell cycle , cancer , psychiatry

The mechanism of spinal cord injury has been thought to be related to the vulnerability of spinal motor neuron cells against ischemia. However, the mechanisms of such vulnerability are not fully understood. We hypothesized that spinal motor neurons might be lost by programmed cell death and investigated a possible mechanism of neuronal death by detection of double-strand breaks in genomic DNA and immunohistochemical analysis for cyclin D1 and cyclin-dependent kinases (Cdk) 4.

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