Hyperglycemia Enhances Extracellular Glutamate Accumulation in Rats Subjected to Forebrain Ischemia | Zendy

Ping-An Li | Zendy; Ashfaq Shuaib | Zendy; Hiro Miyashita | Zendy; Qingping He | Zendy; Bo K. Siesjö | Zendy

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Hyperglycemia Enhances Extracellular Glutamate Accumulation in Rats Subjected to Forebrain Ischemia

Author(s) -

Ping-An Li,

Ashfaq Shuaib,

Hiro Miyashita,

Qingping He,

Bo K. Siesjö

Publication year - 2000

Publication title -

stroke

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.397

H-Index - 319

eISSN - 1524-4628

pISSN - 0039-2499

DOI - 10.1161/01.str.31.1.183

Subject(s) - glutamate receptor , neocortex , extracellular , ischemia , taurine , medicine , endocrinology , hippocampus , glutamine , cerebral cortex , forebrain , anesthesia , central nervous system , biology , amino acid , biochemistry , receptor , psychiatry

An increase in serum glucose at the time of acute ischemia has been shown to adversely affect prognosis. The mechanisms for the hyperglycemia-exacerbated damage are not fully understood. The objective of this study was to determine whether hyperglycemia leads to enhanced accumulation of extracellular concentrations of excitatory amino acids and whether such increases correlate with the histopathological outcome.

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