Effect of Ganaxolone in a Rodent Model of Cerebral Hematoma | Zendy

Patrick Lyden | Zendy; Caroline Shin | Zendy; Catherine Jackson-Friedman | Zendy; Steven Hassid | Zendy; Anthony Chong | Zendy

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Effect of Ganaxolone in a Rodent Model of Cerebral Hematoma

Author(s) -

Patrick Lyden,

Caroline Shin,

Catherine Jackson-Friedman,

Steven Hassid,

Anthony Chong

Publication year - 2000

Publication title -

stroke

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.397

H-Index - 319

eISSN - 1524-4628

pISSN - 0039-2499

DOI - 10.1161/01.str.31.1.169

Subject(s) - medicine , pregnanolone , neuroactive steroid , hematoma , anesthesia , intracerebral hemorrhage , brain damage , pharmacology , gabaa receptor , surgery , receptor , subarachnoid hemorrhage

Therapy with gamma-aminobutyric acid (GABA) agonists appears to improve outcome after experimental hematoma but with unacceptable side effects. We looked to synthetic GABA agonists, or positive GABA modulators, widely developed as anticonvulsants and anxiolytics, to find compounds that may be effective. Ganaxolone is a synthetic neuroactive steroid that positively modulates GABA. We sought to determine whether ganaxolone was beneficial using a model of intracerebral hematoma.

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