Neuroprotective Effects of Female Gonadal Steroids in Reproductively Senescent Female Rats | Zendy

Nabil J. Alkayed | Zendy; Stephanie J. Murphy | Zendy; Richard J. Traystman | Zendy; Patricia D. Hurn | Zendy

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Neuroprotective Effects of Female Gonadal Steroids in Reproductively Senescent Female Rats

Author(s) -

Nabil J. Alkayed,

Stephanie J. Murphy,

Richard J. Traystman,

Patricia D. Hurn

Publication year - 2000

Publication title -

stroke

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.397

H-Index - 319

eISSN - 1524-4628

pISSN - 0039-2499

DOI - 10.1161/01.str.31.1.161

Subject(s) - medicine , estrogen , endocrinology , middle cerebral artery , neuroprotection , ischemia , striatum , stroke (engine) , dopamine , mechanical engineering , engineering

Young adult female rats sustain smaller infarcts after experimental stroke than age-matched males. This sex difference in ischemic brain injury in young animals disappears after surgical ovariectomy and can be restored by estrogen replacement. We sought to determine whether ischemic brain injury continues to be smaller in middle-aged, reproductively senescent female rats compared with age-matched males and to test the effect of ovarian steroids on brain injury after experimental stroke in females.

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