Neuroprotective Properties of Statins in Cerebral Ischemia and Stroke | Zendy

Carl J. Vaughan | Zendy; Norman Delanty | Zendy

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Neuroprotective Properties of Statins in Cerebral Ischemia and Stroke

Author(s) -

Carl J. Vaughan,

Norman Delanty

Publication year - 1999

Publication title -

stroke

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.397

H-Index - 319

eISSN - 1524-4628

pISSN - 0039-2499

DOI - 10.1161/01.str.30.9.1969

Subject(s) - neuroprotection , medicine , stroke (engine) , ischemia , penumbra , pharmacology , brain ischemia , nitric oxide , nitric oxide synthase , cardiology , mechanical engineering , engineering

The atheroma-retarding properties of beta-hydroxy-beta-methylglutaryl coenzyme A reductase (HMG-CoA) inhibitors, or "statins," in both the coronary and carotid arterial beds are well established. However, a growing body of recent data suggests that statins possess important adjunctive properties that may confer additional benefit beyond the retardation of atherosclerosis. In this article, we review the emerging evidence that statins have beneficial effects within the cerebral circulation and brain parenchyma during ischemic stroke and reperfusion.

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