Evaluation of Genetic Risk Factors for Silent Brain Infarction | Zendy

Yoshitomo Notsu | Zendy; Toru Nabika | Zendy; HyunYoung Park | Zendy; Junichi Masuda | Zendy; Shotai Kobayashi | Zendy

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Evaluation of Genetic Risk Factors for Silent Brain Infarction

Author(s) -

Yoshitomo Notsu,

Toru Nabika,

HyunYoung Park,

Junichi Masuda,

Shotai Kobayashi

Publication year - 1999

Publication title -

stroke

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.397

H-Index - 319

eISSN - 1524-4628

pISSN - 0039-2499

DOI - 10.1161/01.str.30.9.1881

Subject(s) - methylenetetrahydrofolate reductase , medicine , genotype , gene polymorphism , cerebral infarction , gastroenterology , genetics , gene , biology , ischemia

Silent brain infarction (SBI) is often found with white matter hyperintensity. A recent genetic study on elderly twins indicated that the susceptibility to white matter hyperintensity was largely determined by genetic factors, implying the existence of genetic susceptibility for SBI as well. We therefore studied 3 genetic polymorphisms in SBI, the deletion/insertion polymorphism of angiotensin-converting enzyme (ACE) gene, the apolipoprotein(a) [apo(a)] size polymorphism, and the T677C polymorphism of methylenetetrahydrofolate reductase (MTHFR) gene, by a case-control study.

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