Pharmacological Inhibition of the Na+/Ca2+Exchanger Enhances Depolarizations Induced by Oxygen/Glucose Deprivation but Not Responses to Excitatory Amino Acids in Rat Striatal Neurons | Zendy

Paolo Calabresi | Zendy; Girolama Alessandra Marfia | Zendy; Salvatore Amoroso | Zendy; Antonio Pisani | Zendy; Giorgio Bernardi | Zendy

Open Access

Pharmacological Inhibition of the Na⁺/Ca²⁺Exchanger Enhances Depolarizations Induced by Oxygen/Glucose Deprivation but Not Responses to Excitatory Amino Acids in Rat Striatal Neurons

Author(s) -

Paolo Calabresi,

Girolama Alessandra Marfia,

Salvatore Amoroso,

Antonio Pisani,

Giorgio Bernardi

Publication year - 1999

Publication title -

stroke

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.397

H-Index - 319

eISSN - 1524-4628

pISSN - 0039-2499

DOI - 10.1161/01.str.30.8.1687

Subject(s) - bepridil , depolarization , excitatory postsynaptic potential , membrane potential , biophysics , excitotoxicity , medicine , intracellular , endocrinology , biochemistry , chemistry , calcium , pharmacology , verapamil , biology , nmda receptor , receptor

Neuronal Na(+)/Ca(2+) exchanger plays a relevant role in maintaining intracellular Ca(2+) and Na(+) levels under physiological and pathological conditions. However, the role of this exchanger in excitotoxicity and ischemia-induced neuronal injury is still controversial and has never been studied in the same neuronal subtypes.

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