Combined Diffusion and Perfusion MRI With Correlation to Single-Photon Emission CT in Acute Ischemic Stroke
Author(s) -
Jari O. Karonen,
Ritva Vanninen,
Yawu Liu,
Leif Østergaard,
Jyrki T. Kuikka,
Juho Nuutinen,
Esko Vanninen,
P Partanen,
Pauli Vainio,
Katja Korhonen,
Jussi Perkiö,
Reina Roivainen,
Juhani Sivenius,
Hannu J. Aronen
Publication year - 1999
Publication title -
stroke
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.397
H-Index - 319
eISSN - 1524-4628
pISSN - 0039-2499
DOI - 10.1161/01.str.30.8.1583
Subject(s) - medicine , penumbra , perfusion , nuclear medicine , stroke (engine) , cerebral blood flow , perfusion scanning , thrombolysis , diffusion mri , infarction , magnetic resonance imaging , single photon emission computed tomography , acute stroke , radiology , cardiology , ischemia , myocardial infarction , tissue plasminogen activator , mechanical engineering , engineering
More effective imaging methods are needed to overcome the limitations of CT in the investigation of treatments for acute ischemic stroke. Diffusion-weighted MRI (DWI) is sensitive in detecting infarcted brain tissue, whereas perfusion-weighted MRI (PWI) can detect brain perfusion in the same imaging session. Combining these methods may help in identifying the ischemic penumbra, which is an important concept in the hemodynamics of acute stroke. The purpose of this study was to determine whether combined DWI and PWI in acute (<24 hours) ischemic stroke can predict infarct growth and final size.
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