The Neuroprotective Effect of the Novel AMPA Receptor Antagonist PD152247 (PNQX) in Temporary Focal Ischemia in the Rat | Zendy

Gerald P. Schielke | Zendy; Nancy C. Kupina | Zendy; Peter A. Boxer | Zendy; Christopher F. Bigge | Zendy; Devin Welty | Zendy

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The Neuroprotective Effect of the Novel AMPA Receptor Antagonist PD152247 (PNQX) in Temporary Focal Ischemia in the Rat

Author(s) -

Gerald P. Schielke,

Nancy C. Kupina,

Peter A. Boxer,

Christopher F. Bigge,

Devin Welty

Publication year - 1999

Publication title -

stroke

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.397

H-Index - 319

eISSN - 1524-4628

pISSN - 0039-2499

DOI - 10.1161/01.str.30.7.1472

Subject(s) - ampa receptor , medicine , neuroprotection , ischemia , antagonist , glutamate receptor , pharmacology , hypothermia , receptor antagonist , anesthesia , lesion , receptor , pathology

Evidence suggests that glutamate contributes to ischemic brain damage through activation of the alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate (AMPA) receptor. We tested the novel, selective AMPA receptor antagonist PD152247 (PNQX) in a model of temporary focal ischemia to determine the dose-response relationship and to investigate the contribution of drug-induced hypothermia to the neuroprotective action of AMPA receptor antagonists.

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