Uncoupling of Oxygen and Glucose Metabolism in Persistent Crossed Cerebellar Diaschisis | Zendy

Hiroshi Yamauchi | Zendy; Hidenao Fukuyama | Zendy; Yasuhiro Nagahama | Zendy; Sadahiko Nishizawa | Zendy; Junji Konishi | Zendy

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Uncoupling of Oxygen and Glucose Metabolism in Persistent Crossed Cerebellar Diaschisis

Author(s) -

Hiroshi Yamauchi,

Hidenao Fukuyama,

Yasuhiro Nagahama,

Sadahiko Nishizawa,

Junji Konishi

Publication year - 1999

Publication title -

stroke

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.397

H-Index - 319

eISSN - 1524-4628

pISSN - 0039-2499

DOI - 10.1161/01.str.30.7.1424

Subject(s) - cerebral blood flow , medicine , oxygen , cerebellum , carbohydrate metabolism , endocrinology , blood flow , pathophysiology , stroke (engine) , apparent oxygen utilisation , glucose uptake , metabolism , cerebellar cortex , anesthesia , chemistry , insulin , mechanical engineering , organic chemistry , engineering

The pathophysiology of deafferentation-induced changes after stroke remains unclear. Some supratentorial strokes cause persistent decreases in blood flow and metabolism in the contralateral cerebellum (persistent crossed cerebellar diaschisis[CCD]). Our previous study showed uncoupling of oxygen consumption and blood flow in this condition, which may reflect a characteristic change in brain metabolism caused by deafferentation. This uncoupling might be related to oxidation of some substrates other than blood-borne glucose, which could also lead to the uncoupling of oxygen consumption and glucose utilization. The purpose of this study was to investigate whether oxygen consumption is uncoupled from glucose utilization in persistent CCD.

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