Attenuation of Thrombin-Induced Brain Edema by Cerebral Thrombin Preconditioning | Zendy

Guohua Xi | Zendy; Richard F. Keep | Zendy; Ya Hua | Zendy; Jianming Xiang | Zendy; Julian T. Hoff | Zendy

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Attenuation of Thrombin-Induced Brain Edema by Cerebral Thrombin Preconditioning

Author(s) -

Guohua Xi,

Richard F. Keep,

Ya Hua,

Jianming Xiang,

Julian T. Hoff

Publication year - 1999

Publication title -

stroke

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.397

H-Index - 319

eISSN - 1524-4628

pISSN - 0039-2499

DOI - 10.1161/01.str.30.6.1247

Subject(s) - thrombin , medicine , intracerebral hemorrhage , edema , pharmacology , anesthesia , cerebral edema , thrombomodulin , endocrinology , platelet , subarachnoid hemorrhage

Edema formation after intracerebral hemorrhage has been linked to thrombin toxicity induced by the clot. However, thrombin at low concentrations actually protects neurons and astrocytes in culture from hypoglycemic and ischemic cell death. It is also known that a brief episode of brain ischemia increases neuronal tolerance to a subsequent severe ischemic episode. The objective of this study was to investigate whether pretreatment of the brain with low-dose thrombin induces tolerance to a subsequent large dose of thrombin injected into brain parenchyma.

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