Hyperhomocysteinemia and Hypofibrinolysis in Young Adults With Ischemic Stroke | Zendy

Bjarne Winther Kristensen | Zendy; Jan Malm | Zendy; Torbjörn Nilsson | Zendy; Johan Hultdin | Zendy; Bo Carlberg | Zendy; Gösta Dahlén | Zendy; Tommy Olsson | Zendy

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Hyperhomocysteinemia and Hypofibrinolysis in Young Adults With Ischemic Stroke

Author(s) -

Bjarne Winther Kristensen,

Jan Malm,

Torbjörn Nilsson,

Johan Hultdin,

Bo Carlberg,

Gösta Dahlén,

Tommy Olsson

Publication year - 1999

Publication title -

stroke

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.397

H-Index - 319

eISSN - 1524-4628

pISSN - 0039-2499

DOI - 10.1161/01.str.30.5.974

Subject(s) - medicine , hyperhomocysteinemia , homocysteine , methylenetetrahydrofolate reductase , stroke (engine) , gastroenterology , genotype , plasminogen activator , methionine , risk factor , case control study , endocrinology , cardiology , surgery , genetics , engineering , mechanical engineering , amino acid , biology , gene

Data from epidemiological and case-control studies suggest that increased total homocysteine (tHcy) levels are associated with increased risk for thromboembolic disease. The mechanisms by which hyperhomocysteinemia contributes to thrombogenesis are incompletely understood. The main objectives of this study of young ischemic stroke patients were (1) to examine fasting and post-methionine load levels of tHcy, (2) to ascertain the genotype frequency of the C677CT mutation in the methylenetetrahydrofolate reductase gene (TT genotype), and (3) to study the possible interaction between plasma tHcy levels and fibrinolytic factors.

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