Open AccessEvidence of Anaphylaxy After Alteplase Infusion
Author(s) -
Jobst Rudolf,
Martin Grond,
William S. Prince,
Susanne Schmülling,
Wolf-Dieter Heiß
Publication year - 1999
Publication title -
stroke
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.397
H-Index - 319
eISSN - 1524-4628
pISSN - 0039-2499
DOI - 10.1161/01.str.30.5.1142
Subject(s) - medicine , anesthesia , thrombolysis , anaphylaxis , immunoglobulin e , asymptomatic , complication , anaphylactic reaction , antibody , immunology , allergy , myocardial infarction
Although alteplase, a recombinant tissue plasminogen activator (tPA), is structurally identical to endogenous tPA and therefore should not induce allergy, single cases of acute hypersensitivity reactions have been reported. Until now, specific antibodies against alteplase were not detected in blood samples obtained in these patients.
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