Influence of Platelet-Activating Factor on Cerebral Microcirculation in Rats | Zendy

Eberhard Uhl | Zendy; Sven Pickelmann | Zendy; A. Baethmann | Zendy; L. Schürer | Zendy

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Influence of Platelet-Activating Factor on Cerebral Microcirculation in Rats

Author(s) -

Eberhard Uhl,

Sven Pickelmann,

A. Baethmann,

L. Schürer

Publication year - 1999

Publication title -

stroke

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.397

H-Index - 319

eISSN - 1524-4628

pISSN - 0039-2499

DOI - 10.1161/01.str.30.4.873

Subject(s) - platelet activating factor , medicine , microcirculation , endothelium , platelet , shock (circulatory) , endocrinology , nitric oxide , perfusion , anesthesia

Platelet-activating factor (PAF) has been demonstrated to have a mediator function in shock, with some of its deleterious effects being attributed to its influence on microcirculation. Systemic PAF concentrations as found in shock could also compromise the cerebral microcirculation. Our purpose in the present study was to examine the influence of systemically applied PAF on microvascular perfusion and leukocyte-endothelium interactions in cerebral microvessels.

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