Open AccessContinuing Postischemic Neuronal Death in CA1
Author(s) -
Frederick Colbourne,
Hui Li,
Alastair M. Buchan
Publication year - 1999
Publication title -
stroke
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.397
H-Index - 319
eISSN - 1524-4628
pISSN - 0039-2499
DOI - 10.1161/01.str.30.3.662
Subject(s) - medicine , ischemia , nbqx , antagonist , neuroprotection , necrosis , anesthesia , occlusion , ampa receptor , pharmacology , nmda receptor , receptor
Transient forebrain ischemia results in a 24- to 72-hour delayed loss of CA1 neurons. Previous work has not assessed whether insult durations can vary the degree and maturation rate of CA1 injury and whether there are different ultrastructural features of death after brief or severe ischemia. We also tested whether known cytoprotective drugs achieve permanent or transient neuroprotection.
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