Prevention of Neointimal Formation by a Serine Protease Inhibitor, FUT-175, After Carotid Balloon Injury in Rats | Zendy

Motoshi Sawada | Zendy; Hiroji Yanamoto | Zendy; Izumi Nagata | Zendy; Nobuo Hashimoto | Zendy; Ichiro NAKAHARA | Zendy; Yoshinori Akiyama | Zendy; H Kikuchi | Zendy

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Prevention of Neointimal Formation by a Serine Protease Inhibitor, FUT-175, After Carotid Balloon Injury in Rats

Author(s) -

Motoshi Sawada,

Hiroji Yanamoto,

Izumi Nagata,

Nobuo Hashimoto,

Ichiro NAKAHARA,

Yoshinori Akiyama,

H Kikuchi

Publication year - 1999

Publication title -

stroke

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.397

H-Index - 319

eISSN - 1524-4628

pISSN - 0039-2499

DOI - 10.1161/01.str.30.3.644

Subject(s) - medicine , restenosis , saline , lesion , neointima , balloon , serine protease , pathology , protease , stent , biochemistry , chemistry , enzyme

In vivo and vitro studies revealed the activation of thrombin and the complement system in vascular lesion formation during the process of atherosclerosis, along with pathological proliferation of smooth muscle cells. We examined the effect of the synthetic serine protease inhibitor FUT-175 (developed as a potent inhibitor of thrombin and the complement system) on vascular lesions using balloon dilatation-induced neointimal formation in the carotid artery of rats.

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