Gene Transfer of Human Prostacyclin Synthase Prevents Neointimal Formation After Carotid Balloon Injury in Rats | Zendy

Tatemi Todaka | Zendy; Chieko Yokoyama | Zendy; Hiroji Yanamoto | Zendy; Nobuhiro Hashimoto | Zendy; Isao Nagata | Zendy; Tohru Tsukahara | Zendy; Shuntaro Hara | Zendy; Toshihisa Hatae | Zendy; Ryuichi Morishita | Zendy; Motokuni Aoki | Zendy; Toshio Ogihara | Zendy; Yasufumi Kaneda | Zendy; Tadashi Tanabe | Zendy

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Gene Transfer of Human Prostacyclin Synthase Prevents Neointimal Formation After Carotid Balloon Injury in Rats

Author(s) -

Tatemi Todaka,

Chieko Yokoyama,

Hiroji Yanamoto,

Nobuhiro Hashimoto,

Isao Nagata,

Tohru Tsukahara,

Shuntaro Hara,

Toshihisa Hatae,

Ryuichi Morishita,

Motokuni Aoki,

Toshio Ogihara,

Yasufumi Kaneda,

Tadashi Tanabe

Publication year - 1999

Publication title -

stroke

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.397

H-Index - 319

eISSN - 1524-4628

pISSN - 0039-2499

DOI - 10.1161/01.str.30.2.419

Subject(s) - medicine , prostacyclin , gene transfer , balloon , cardiology , gene , biochemistry , chemistry

A disordered proliferative process in the vascular wall is thought to underlie the pathogenesis of restenosis after percutaneous transluminal angioplasty and carotid endarterectomy. A growth inhibitory property of overexpressed prostacyclin (PGI2) synthase (PGIS) was recently implicated in the pathological proliferation of vascular smooth muscle cells (VSMC) in vitro. Here, we investigated the effects of increased PGI2 synthesis on the pathological proliferation of VSMCs.

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