Characterization of White Matter Damage in Ischemic Leukoaraiosis with Diffusion Tensor MRI | Zendy

Derek K. Jones | Zendy; David J. Lythgoe | Zendy; Mark A. Horsfield | Zendy; Andrew Simmons | Zendy; Steven Williams | Zendy; Hugh S. Markus | Zendy

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Characterization of White Matter Damage in Ischemic Leukoaraiosis with Diffusion Tensor MRI

Author(s) -

Derek K. Jones,

David J. Lythgoe,

Mark A. Horsfield,

Andrew Simmons,

Steven Williams,

Hugh S. Markus

Publication year - 1999

Publication title -

stroke

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.397

H-Index - 319

eISSN - 1524-4628

pISSN - 0039-2499

DOI - 10.1161/01.str.30.2.393

Subject(s) - leukoaraiosis , diffusion mri , white matter , fractional anisotropy , medicine , pathology , magnetic resonance imaging , nuclear magnetic resonance , radiology , physics

Information on the neuropathological changes underlying ischemic leukoaraiosis is only available postmortem, and there are limited data on histological appearances early in the disease. Diffusion tensor imaging allows determination of the directionality of diffusion, which is greater in the direction of white matter bundles. Therefore, the technique might be expected to show loss of anisotropy (directional diffusion) in leukoaraiosis.

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