Clinical Severity in CADASIL Related to Ultrastructural Damage in White Matter | Zendy

Hugues Chabriat | Zendy; Sabina Pappatà | Zendy; Cyril Poupon | Zendy; Chris A. Clark | Zendy; Katayoun Vahedi | Zendy; Fabrice Poupon | Zendy; JeanFrançois Mangin | Zendy; Mathilde PachotClouard | Zendy; Antoinette Jobert | Zendy; Denis Le Bihan | Zendy; M G Bousser | Zendy

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Clinical Severity in CADASIL Related to Ultrastructural Damage in White Matter

Author(s) -

Hugues Chabriat,

Sabina Pappatà,

Cyril Poupon,

Chris A. Clark,

Katayoun Vahedi,

Fabrice Poupon,

JeanFrançois Mangin,

Mathilde PachotClouard,

Antoinette Jobert,

Denis Le Bihan,

M G Bousser

Publication year - 1999

Publication title -

stroke

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.397

H-Index - 319

eISSN - 1524-4628

pISSN - 0039-2499

DOI - 10.1161/01.str.30.12.2637

Subject(s) - hyperintensity , medicine , white matter , cadasil , diffusion mri , fractional anisotropy , magnetic resonance imaging , stroke (engine) , pathology , cardiology , radiology , leukoencephalopathy , mechanical engineering , engineering

CADASIL is a newly recognized cause of subcortical ischemic strokes that progressively leads to dementia associated with pseudobulbar palsy and severe motor disability. This deleterious progression and the severity of clinical presentation are widely variable among affected subjects. The exact role played by MRI white-matter abnormalities, a hallmark of the disease, in the severity of the clinical phenotype remains poorly understood.

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