A Randomized Efficacy Trial of Citicoline in Patients With Acute Ischemic Stroke | Zendy

Wayne M. Clark | Zendy; Benjamin J. Williams | Zendy; Kenneth A. Selzer | Zendy; Richard M. Zweifler | Zendy; LuAnn Sabounjian | Zendy; Richard E. Gammans | Zendy

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A Randomized Efficacy Trial of Citicoline in Patients With Acute Ischemic Stroke

Author(s) -

Wayne M. Clark,

Benjamin J. Williams,

Kenneth A. Selzer,

Richard M. Zweifler,

LuAnn Sabounjian,

Richard E. Gammans

Publication year - 1999

Publication title -

stroke

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.397

H-Index - 319

eISSN - 1524-4628

pISSN - 0039-2499

DOI - 10.1161/01.str.30.12.2592

Subject(s) - citicoline , medicine , placebo , stroke (engine) , modified rankin scale , randomized controlled trial , anesthesia , ischemia , ischemic stroke , mechanical engineering , alternative medicine , pathology , engineering

Citicoline (cytidine-5'-diphosphocholine; CDP-choline) may reduce central nervous system ischemic injury by stabilizing cell membranes and reducing free radical generation. A previous dose-comparison trial in patients with acute stroke found that 500 mg of citicoline appeared to improve neurological outcome with minimal side effects.

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