A Deletion Polymorphism of α2-Macroglobulin Gene and Cerebral Amyloid Angiopathy | Zendy

Masahito Yamada | Zendy; Nobuyuki Sodeyama | Zendy; Yoshinori Itoh | Zendy; Naomi Suematsu | Zendy; E Otomo | Zendy; Masaaki Matsushita | Zendy; Hidehiro Mizusawa | Zendy

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A Deletion Polymorphism of α₂-Macroglobulin Gene and Cerebral Amyloid Angiopathy

Author(s) -

Masahito Yamada,

Nobuyuki Sodeyama,

Yoshinori Itoh,

Naomi Suematsu,

E Otomo,

Masaaki Matsushita,

Hidehiro Mizusawa

Publication year - 1999

Publication title -

stroke

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.397

H-Index - 319

eISSN - 1524-4628

pISSN - 0039-2499

DOI - 10.1161/01.str.30.11.2277

Subject(s) - cerebral amyloid angiopathy , medicine , apolipoprotein e , allele , exon , alzheimer's disease , macroglobulin , polymorphism (computer science) , genotype , degenerative disease , genetics , gene , disease , pathology , dementia , biology

alpha(2)-Macroglobulin may be implicated in amyloid beta protein deposition. A deletion in the exon 18 splice acceptor of the alpha(2)-macroglobulin gene (A2M) has been reported to be associated with risk for Alzheimer's disease (AD). In search of genetic risk factors for cerebral amyloid angiopathy (CAA), we investigated association of the A2M deletion polymorphism with CAA.

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