Chronic Estrogen Treatment Increases Levels of Endothelial Nitric Oxide Synthase Protein in Rat Cerebral Microvessels | Zendy

Anne Marie McNeill | Zendy; Nancy Kim | Zendy; Sue Piper Duckles | Zendy; Dia. Krause | Zendy

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Chronic Estrogen Treatment Increases Levels of Endothelial Nitric Oxide Synthase Protein in Rat Cerebral Microvessels

Author(s) -

Anne Marie McNeill,

Nancy Kim,

Sue Piper Duckles,

Dia. Krause

Publication year - 1999

Publication title -

stroke

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.397

H-Index - 319

eISSN - 1524-4628

pISSN - 0039-2499

DOI - 10.1161/01.str.30.10.2186

Subject(s) - enos , ovariectomized rat , endocrinology , medicine , estrogen , endothelial nos , nitric oxide synthase type iii , nitric oxide synthase , nitric oxide

A number of studies indicate that the female gonadal hormone, estrogen, confers protection against cerebrovascular disorders such as stroke. One postulated mechanism for these effects of estrogen is an action on the enzyme endothelial nitric oxide synthase (eNOS), which produces the vasodilatory molecule NO. We have investigated the hypothesis that estrogen increases expression of eNOS in cerebral microvessels of male and female rats.

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