Sodium Influx Plays a Major Role in the Membrane Depolarization Induced by Oxygen and Glucose Deprivation in Rat Striatal Spiny Neurons | Zendy

Paolo Calabresi | Zendy; Girolama Alessandra Marfia | Zendy; Diego Centonze | Zendy; Antonio Pisani | Zendy; Giorgio Bernardi | Zendy

Open Access

Sodium Influx Plays a Major Role in the Membrane Depolarization Induced by Oxygen and Glucose Deprivation in Rat Striatal Spiny Neurons

Author(s) -

Paolo Calabresi,

Girolama Alessandra Marfia,

Diego Centonze,

Antonio Pisani,

Giorgio Bernardi

Publication year - 1999

Publication title -

stroke

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.397

H-Index - 319

eISSN - 1524-4628

pISSN - 0039-2499

DOI - 10.1161/01.str.30.1.171

Subject(s) - depolarization , medicine , medium spiny neuron , sodium , membrane potential , neuroscience , striatum , endocrinology , biophysics , dopamine , biology , chemistry , organic chemistry

Striatal spiny neurons are selectively vulnerable to ischemia, but the ionic mechanisms underlying this selective vulnerability are unclear. Although a possible involvement of sodium and calcium ions has been postulated in the ischemia-induced damage of rat striatal neurons, the ischemia-induced ionic changes have never been analyzed in this neuronal subtype.

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