Effects of Glucose and Pa o 2 Modulation on Cortical Intracellular Acidosis, NADH Redox State, and Infarction in the Ischemic Penumbra | Zendy

Robert E. Anderson | Zendy; William K M Tan | Zendy; Heidi S. Martin | Zendy; Fredric B. Meyer | Zendy

Open Access

Effects of Glucose and Pa o ₂ Modulation on Cortical Intracellular Acidosis, NADH Redox State, and Infarction in the Ischemic Penumbra

Author(s) -

Robert E. Anderson,

William K M Tan,

Heidi S. Martin,

Fredric B. Meyer

Publication year - 1999

Publication title -

stroke

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.397

H-Index - 319

eISSN - 1524-4628

pISSN - 0039-2499

DOI - 10.1161/01.str.30.1.160

Subject(s) - penumbra , acidosis , medicine , ischemia , hypoglycemia , intracellular ph , lactic acidosis , endocrinology , infarction , anesthesia , intracellular , cardiology , biochemistry , biology , myocardial infarction , insulin

During focal cerebral ischemia, the ischemic penumbra or border-zone regions of moderate cortical blood flow reductions have a heterogeneous development of intracellular cortical acidosis. This experiment tested the hypotheses that (1) this acidosis is secondary to glucose utilization and (2) this intracellular acidosis leads to recruitment of potentially salvageable tissue into infarction.

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