Osteogenic Protein-1 Protects Against Cerebral Infarction Induced by MCA Ligation in Adult Rats | Zendy

ShinnZong Lin | Zendy; Barry J. Hoffer | Zendy; Paul L. Kaplan | Zendy; Yun Wang | Zendy

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Osteogenic Protein-1 Protects Against Cerebral Infarction Induced by MCA Ligation in Adult Rats

Author(s) -

ShinnZong Lin,

Barry J. Hoffer,

Paul L. Kaplan,

Yun Wang

Publication year - 1999

Publication title -

stroke

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.397

H-Index - 319

eISSN - 1524-4628

pISSN - 0039-2499

DOI - 10.1161/01.str.30.1.126

Subject(s) - medicine , ligation , cerebral infarction , stroke (engine) , infarction , cardiology , ischemia , myocardial infarction , mechanical engineering , engineering

Osteogenic protein-1 (OP1) not only possesses trophic activity on bone tissue but also influences neuronal survival and differentiation in vitro. Specific receptors for OP1 are present in brain and spinal cord and can be upregulated during cerebral contusion. OP1 is a member of the transforming growth factor-beta superfamily, several of whose members possess neuroprotective activity. In this study, the neuroprotective effect of OP1 in cerebral ischemia was evaluated in adult animals.

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