Adenovirus-Mediated Gene Transfer Is Augmented in Basilar and Carotid Arteries of Heritable Hyperlipidemic Rabbits | Zendy

Donald D. Lund | Zendy; Frank M. Faraci | Zendy; Hiroaki Ooboshi | Zendy; Beverly L. Davidson | Zendy; Donald D. Heistad | Zendy

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Adenovirus-Mediated Gene Transfer Is Augmented in Basilar and Carotid Arteries of Heritable Hyperlipidemic Rabbits

Author(s) -

Donald D. Lund,

Frank M. Faraci,

Hiroaki Ooboshi,

Beverly L. Davidson,

Donald D. Heistad

Publication year - 1999

Publication title -

stroke

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.397

H-Index - 319

eISSN - 1524-4628

pISSN - 0039-2499

DOI - 10.1161/01.str.30.1.120

Subject(s) - medicine , basilar artery , carotid arteries , gene transfer , cerebral arteries , stroke (engine) , cardiology , gene , anatomy , genetics , biology , mechanical engineering , engineering

There are major differences in susceptibility of intracranial and extracranial arteries to atherosclerosis. The goal of this study was to examine adenovirus-mediated gene transfer to basilar and carotid arteries of Watanabe heritable hyperlipidemic (WHHL) rabbits, which have spontaneous hypercholesterolemia and atherosclerosis, and normal New Zealand White (NZW) rabbits. We used 2 different adenoviral vectors, driven by either cytomegalovirus (CMV) or Rous sarcoma virus (RSV) promoters.

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