Behavioral Testing Does Not Exacerbate Ischemic CA1 Damage in Gerbils
Author(s) -
Frederick Colbourne,
Roland N. Auer,
Garnette R. Sutherland
Publication year - 1998
Publication title -
stroke
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.397
H-Index - 319
eISSN - 1524-4628
pISSN - 0039-2499
DOI - 10.1161/01.str.29.9.1967
Subject(s) - medicine , neuroprotection , hippocampal formation , hypothermia , ischemia , hippocampus , ischemic injury , anesthesia , open field , neuroscience , traumatic brain injury , pharmacology , psychiatry , psychology
Previous research studying ablative lesions has suggested that functional use may exacerbate brain injury. If true, this would have considerable ramifications not only for the mechanistic understanding of neuronal injury but also for the clinical use of physiotherapy. In this report the hypothesis that behavioral use of brain tissue exacerbates ischemic hippocampal injury was tested.
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