High Prevalence of Antiphosphatidylinositol Antibodies in Young Patients With Cerebral Ischemia of Undetermined Cause | Zendy

Vincenzo Toschi | Zendy; Adele Motta | Zendy; Carlo Castelli | Zendy; Maria Luisa Paracchini | Zendy; D Zerbi | Zendy; A Gibelli | Zendy

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High Prevalence of Antiphosphatidylinositol Antibodies in Young Patients With Cerebral Ischemia of Undetermined Cause

Author(s) -

Vincenzo Toschi,

Adele Motta,

Carlo Castelli,

Maria Luisa Paracchini,

D Zerbi,

A Gibelli

Publication year - 1998

Publication title -

stroke

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.397

H-Index - 319

eISSN - 1524-4628

pISSN - 0039-2499

DOI - 10.1161/01.str.29.9.1759

Subject(s) - medicine , ischemia , stroke (engine) , antibody , cardiology , immunology , mechanical engineering , engineering

Anticardiolipin antibodies (aCL) are associated with thrombotic phenomena including cerebral ischemia in young adults. Although aCL are directed to a neoepitope formed by phospholipid and beta2-glycoprotein I (beta2-GPI), immunoassays based on cardiolipin as target antigen are widely used. We previously demonstrated that 47% of aCL-negative systemic lupus erythematosus (SLE) patients had antiphospholipid antibodies (aPL) to epitopes other than cardiolipin, and we found an association between aPL to noncardiolipin antigens and thrombosis. We now assess the prevalence and clinical significance of noncardiolipin aPL in young adults with cerebrovascular disease of undetermined etiology.

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