Normoxic Ventilation After Cardiac Arrest Reduces Oxidation of Brain Lipids and Improves Neurological Outcome | Zendy

Yuanbin Liu | Zendy; Robert E. Rosenthal | Zendy; Yolanda Haywood | Zendy; Milena Miljkovic-Lolic | Zendy; Jack Y. Vanderhoek | Zendy; Gary Fiskum | Zendy

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Normoxic Ventilation After Cardiac Arrest Reduces Oxidation of Brain Lipids and Improves Neurological Outcome

Author(s) -

Yuanbin Liu,

Robert E. Rosenthal,

Yolanda Haywood,

Milena Miljkovic-Lolic,

Jack Y. Vanderhoek,

Gary Fiskum

Publication year - 1998

Publication title -

stroke

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.397

H-Index - 319

eISSN - 1524-4628

pISSN - 0039-2499

DOI - 10.1161/01.str.29.8.1679

Subject(s) - medicine , resuscitation , ventilation (architecture) , cardiopulmonary resuscitation , anesthesia , oxygenation , return of spontaneous circulation , ischemia , mechanical engineering , engineering

Increasing evidence that oxidative stress contributes to delayed neuronal death after global cerebral ischemia has led to reconsideration of the prolonged use of 100% ventilatory O2 following resuscitation from cardiac arrest. This study determined the temporal course of oxidation of brain fatty acyl groups in a clinically relevant canine model of cardiac arrest and resuscitation and tested the hypothesis that postischemic ventilation with 21% inspired O2, rather than 100% O2, results in reduced levels of oxidized brain lipids and decreased neurological impairment.

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