Identification of a Serum Gelatinase Associated With the Occurrence of Cerebral Aneurysms as Pro-Matrix Metalloproteinase-2 | Zendy

D. Roxanne Todor | Zendy; Isabel M. Lewis | Zendy; Gerry Bruno | Zendy; Douglas Chyatte | Zendy

Open Access

Identification of a Serum Gelatinase Associated With the Occurrence of Cerebral Aneurysms as Pro-Matrix Metalloproteinase-2

Author(s) -

D. Roxanne Todor,

Isabel M. Lewis,

Gerry Bruno,

Douglas Chyatte

Publication year - 1998

Publication title -

stroke

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.397

H-Index - 319

eISSN - 1524-4628

pISSN - 0039-2499

DOI - 10.1161/01.str.29.8.1580

Subject(s) - gelatinase , zymography , medicine , subarachnoid hemorrhage , pmsf , pathology , aneurysm , matrix metalloproteinase , gelatinases , coomassie brilliant blue , blot , phenylmethylsulfonyl fluoride , endocrinology , biochemistry , staining , biology , enzyme , surgery , gene

Subarachnoid hemorrhage from intracranial aneurysm rupture produces a severe form of stroke. Extracellular matrix remodeling is associated with cerebral aneurysms and may play a role in the formation or rupture of these lesions. We previously reported a 3-fold increase in a 72-kDa serum gelatinase in a subgroup of aneurysm patients. The purpose of the present study was to further characterize and identify this gelatinase.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research