A Model of Transient Unilateral Focal Ischemia With Reperfusion in the P7 Neonatal Rat | Zendy

Sylvain Renolleau | Zendy; D. Aggoun-Zouaoui | Zendy; Yehezkel BenAri | Zendy; Christiane CharriautMarlangue | Zendy

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A Model of Transient Unilateral Focal Ischemia With Reperfusion in the P7 Neonatal Rat

Author(s) -

Sylvain Renolleau,

D. Aggoun-Zouaoui,

Yehezkel BenAri,

Christiane CharriautMarlangue

Publication year - 1998

Publication title -

stroke

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.397

H-Index - 319

eISSN - 1524-4628

pISSN - 0039-2499

DOI - 10.1161/01.str.29.7.1454

Subject(s) - medicine , tunel assay , cresyl violet , ischemia , pathology , infarction , occlusion , staining , immunohistochemistry , myocardial infarction

The mechanisms leading to delayed cell death after hypoxic-ischemic injury in the developing brain remain to be elucidated. The aim of this study was to develop a model of transient focal ischemia in the neonatal rat in an attempt to create a reperfusion phase since in the filament model of reversible middle cerebral artery occlusion, size limitations precluded performing this procedure before 14 to 18 days. We then analyze whether apoptosis or necrosis occurs in this model.

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