Reduction of Ischemic Brain Injury by Topical Application of Glial Cell Line–Derived Neurotrophic Factor After Permanent Middle Cerebral Artery Occlusion in Rats | Zendy

Hisashi Kitagawa | Zendy; Takaaki Hayashi | Zendy; Yasuhide Mitsumoto | Zendy; Nobuyuki Koga | Zendy; Yasuto Itoyama | Zendy; K. Abe | Zendy

Open Access

Reduction of Ischemic Brain Injury by Topical Application of Glial Cell Line–Derived Neurotrophic Factor After Permanent Middle Cerebral Artery Occlusion in Rats

Author(s) -

Hisashi Kitagawa,

Takaaki Hayashi,

Yasuhide Mitsumoto,

Nobuyuki Koga,

Yasuto Itoyama,

K. Abe

Publication year - 1998

Publication title -

stroke

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.397

H-Index - 319

eISSN - 1524-4628

pISSN - 0039-2499

DOI - 10.1161/01.str.29.7.1417

Subject(s) - glial cell line derived neurotrophic factor , tunel assay , medicine , neurotrophic factors , dna fragmentation , pathology , apoptosis , anesthesia , immunohistochemistry , programmed cell death , biology , biochemistry , receptor

Glial cell line-derived neurotrophic factor (GDNF) plays important roles in the survival and recovery of some mature neurons under pathological conditions. However, the effect of GDNF in ameliorating ischemic brain injury has not been well documented. Therefore, we investigated a possible effect of GDNF on the changes of infarct size, brain edema, DNA fragmentation, and immunoreactivities for caspases after permanent middle cerebral artery occlusion (MCAO) in rats.

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