Adenovirus-Mediated Gene Transfer In Vivo to Cerebral Blood Vessels and Perivascular Tissue in Mice | Zendy

Stuart D. Christenson | Zendy; Kristy D. Lake | Zendy; Hiroaki Ooboshi | Zendy; Frank M. Faraci | Zendy; Beverly L. Davidson | Zendy; Donald D. Heistad | Zendy

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Adenovirus-Mediated Gene Transfer In Vivo to Cerebral Blood Vessels and Perivascular Tissue in Mice

Author(s) -

Stuart D. Christenson,

Kristy D. Lake,

Hiroaki Ooboshi,

Frank M. Faraci,

Beverly L. Davidson,

Donald D. Heistad

Publication year - 1998

Publication title -

stroke

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.397

H-Index - 319

eISSN - 1524-4628

pISSN - 0039-2499

DOI - 10.1161/01.str.29.7.1411

Subject(s) - medicine , gene transfer , pathology , in vivo , blood vessel , stroke (engine) , perivascular space , anatomy , gene , genetics , biology , mechanical engineering , engineering

Gene transfer to cerebral blood vessels has been accomplished in rats and dogs by injection of replication-deficient adenovirus into cerebrospinal fluid. In this study we examined transgene expression after injection of adenovirus into the cerebrospinal fluid of mice. Responses were observed in ICR mice and C57BL/6 mice, which are outbred and inbred strains, respectively.

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